[冠状动脉血流分级减少时心肌毛细血管床的扩散能力]
[Diffusion capacity of the myocardial capillary bed in graded decrease in the coronary blood flow].
作者信息
Serebriakova L I, Trubetskoĭ A V
出版信息
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1984;7(2):86-92.
In closed chest dogs with controlled perfusion of the left coronary artery coronary blood flow was reduced by 10, 20, 30, 40, 50 and 70%. Diffusion capacity of myocardial capillary bed (permeability surface area product) decreased in all but the first (10%) series of experiments. 23-64% fall of the product occurred irrespective of coronary vessel reserve state but with respect to the degree of blood flow reduction. The amount of coronary influx possibly determined the number of perfused capillaries in the heart. Thus, 20% and more reduction of coronary blood flow cannot be compensated at the level of myocardial capillary bed.
在左冠状动脉灌注受控的开胸犬中，冠状动脉血流量减少了10%、20%、30%、40%、50%和70%。除了第一个（10%）系列实验外，心肌毛细血管床的弥散能力（通透表面积乘积）在所有实验中均降低。无论冠状动脉储备状态如何，该乘积均下降了23%-64%，但与血流量减少的程度有关。冠状动脉流入量可能决定了心脏中灌注毛细血管的数量。因此，冠状动脉血流量减少20%及以上时，心肌毛细血管床水平无法进行代偿。
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