酰基葡萄糖神经酰胺会导致脂质体变平并堆叠。这是表皮渗透屏障组装的一个类比。

Acylglucosylceramide causes flattening and stacking of liposomes. An analogy for assembly of the epidermal permeability barrier.

作者信息

Landmann L, Wertz P W, Downing D T

出版信息

Biochim Biophys Acta. 1984 Dec 19;778(3):412-8. doi: 10.1016/0005-2736(84)90388-2.

Abstract

When 5% of 1-(3'-O-acyl)-beta-D-glucosyl-N-(omega-hydroxyacyl)sphingosine, isolated from pig epidermis, was added to distearoylphosphatidylcholine and cholesterol (10:1), the lipid mixture formed liposomes in phosphate buffer which were flattened and aggregated like stacks of coins. Other glycolipids from pig epidermis did not cause this phenomenon. This supports the hypothesis that the acylglucosylceramide is responsible for assembly of the lamellar granules found in epidermal cells.

摘要

从猪表皮分离出的1-(3'-O-酰基)-β-D-葡萄糖基-N-(ω-羟基酰基)鞘氨醇的5%添加到二硬脂酰磷脂酰胆碱和胆固醇(10:1)中时，该脂质混合物在磷酸盐缓冲液中形成脂质体，这些脂质体扁平且聚集，如同叠放的硬币。猪表皮的其他糖脂不会导致这种现象。这支持了酰基葡萄糖神经酰胺负责表皮细胞中层状颗粒组装的假说。