猪表皮的酰基葡萄糖神经酰胺：结构测定

Acylglucosylceramides of pig epidermis: structure determination.

作者信息

Wertz P W, Downing D T

出版信息

J Lipid Res. 1983 Jun;24(6):753-8.

Abstract

The acylglucosylceramides of pig epidermis comprise 56% of the total glucosylceramides and 3.3% of the total epidermal lipid by weight. Contrary to an earlier report on this lipid, the amide-linked fatty acid is not a dihydroxypentatriacontadienoic acid; rather, the fatty acids are a series of long chain omega-hydroxy acids consisting of 58% saturates, 35% monoenes, and 7% dienes, with predominant chain lengths of 30, 32, and 34 carbons, respectively. The structure of the acylglucosylceramides may therefore be formulated as 1-(3'-O-acyl)-beta-D-glucosyl-N-(omega-hydroxy)acylsphingosines. In accord with the previous report, 74% of the total esterified fatty acids is linoleic acid and the long-chain bases consist of homologous series of sphinganines and sphingenines ranging from 16-22 carbons in length. This unique glycolipid may play a role in epidermal barrier function.

摘要

猪表皮的酰基葡糖神经酰胺占总葡糖神经酰胺的56%，按重量计占表皮总脂质的3.3%。与之前关于这种脂质的报道相反，酰胺连接的脂肪酸不是二羟基三十五碳二烯酸；相反，脂肪酸是一系列长链ω-羟基酸，其中饱和酸占58%，单烯酸占35%，二烯酸占7%，主要链长分别为30、32和34个碳。因此，酰基葡糖神经酰胺的结构可表示为1-(3'-O-酰基)-β-D-葡糖基-N-(ω-羟基)酰基鞘氨醇。与之前的报道一致，总酯化脂肪酸的74%是亚油酸，长链碱由长度为16-22个碳的鞘氨醇和鞘氨醇同系物组成。这种独特的糖脂可能在表皮屏障功能中起作用。