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Inhibition of replicative DNA synthesis in nuclei of Strongylocentrotus intermedium urchin embryo by 2',3'-dideoxy-3'-aminonucleoside 5'-triphosphates.

作者信息

Kukhanova M, Krayevsky A, Terentyeva N, Rasskazov V

出版信息

Biochim Biophys Acta. 1984 Dec 14;783(3):221-6. doi: 10.1016/0167-4781(84)90032-0.

Abstract

2',3'-Dideoxy-3'-aminonucleoside 5'-triphosphates have been shown to be inhibitors of replicative DNA synthesis in isolated nuclei of sea urchin embryo. These compounds inhibit the Okazaki fragment synthesis. The effect of 2',3'-dideoxy-3'-aminothymidine 5'-triphosphate and arabinothymidine 5'-triphosphate is reversible when adding the corresponding substrate for DNA synthesis, 2'-deoxythymidine 5'-triphosphate.

摘要

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