Hoey B M, Butler J
Biochim Biophys Acta. 1984 Dec 7;791(2):212-8. doi: 10.1016/0167-4838(84)90011-6.
Natural and synthetic antioxidants have been shown to repair tryptophan radicals produced from the one-electron oxidation of the free tryptophan amino acid. It has also been observed that both tryptophan and tyrosine radicals in lysozyme can be repaired by these antioxidants to varying degrees of efficiency. Although SDS-solubilized alpha-tocopherol efficiently repairs free tryptophan radicals, it is very inefficient in repairing the amino acids in lysozyme. The rigidity and immobility of solubilized alpha-tocopherol can explain this lack of efficiency.
天然和合成抗氧化剂已被证明能修复由游离色氨酸氨基酸的单电子氧化产生的色氨酸自由基。还观察到，溶菌酶中的色氨酸和酪氨酸自由基都能被这些抗氧化剂不同程度地有效修复。尽管十二烷基硫酸钠溶解的α-生育酚能有效修复游离色氨酸自由基，但在修复溶菌酶中的氨基酸方面效率很低。溶解的α-生育酚的刚性和固定性可以解释这种效率低下的原因。
