Salmona G, Assaf A, Gayte-Sorbier A, Airaudo C B
Biomed Mass Spectrom. 1984 Sep;11(9):450-4. doi: 10.1002/bms.1200110903.
Five benzothiazole derivatives leached into injections by the rubber plunger-seals of disposable syringes were identified by electron impact (EI) and chemical ionization (CI) mass spectrometry. These are 2-hydroxybenzothiazole, 2-mercaptobenzothiazole, 2-(methylmercapto)benzothiazole, 2-(2-hydroxyethoxy)benzothiazole and 2-(2-hydroxyethylmercapto)benzothiazole. 2-Mercaptobenzothiazole is used as a vulcanization accelerator. The other four compounds are formed from the zinc derivative of 2-mercaptobenzothiazole during sterilization with ethylene oxide. Toxicological, technological and legal consequences of the leaching are discussed briefly.
通过电子轰击（EI）和化学电离（CI）质谱法鉴定出一次性注射器的橡胶活塞密封件渗入注射液中的五种苯并噻唑衍生物。它们是2-羟基苯并噻唑、2-巯基苯并噻唑、2-（甲基巯基）苯并噻唑、2-（2-羟基乙氧基）苯并噻唑和2-（2-羟乙基巯基）苯并噻唑。2-巯基苯并噻唑用作硫化促进剂。其他四种化合物是在环氧乙烷灭菌过程中由2-巯基苯并噻唑的锌衍生物形成的。简要讨论了浸出的毒理学、技术和法律后果。
