Popkova N I, Kernitskiĭ B S, Sorochinskaia E P, Iurkov V A, Kucherenko N E
Biull Eksp Biol Med. 1984 Nov;98(11):525-7.
A study was made of the effect of salmonellosis endotoxin (SE) on the activity of glutathione transferase (GT), glutathione peroxidase (GP-GTB and GP-H2O2), glutathione reductase (GR) and superoxide dismutase (SOD) in cytosols of the rat jejunal mucosa and liver. The activity of all the test enzymes of both the small intestine and liver was marked by drastic changes at the early stages of SE action. Thus, the activity of SOD and GP-H2O2 in the liver decreased after 30 min or 1 h of endotoxin action, respectively. In the jejunal mucosa, the activity of GP-H2O2 and SOD dropped after 4 h of SE action. GT in the jejunum remained unchanged, whereas in the liver, it was activated. The activity of GR and GP-GTB in the liver and jejunum was dissimilar. The causes and consequences of the abnormalities of the antioxidant enzymatic system and the role they play in the pathogenesis of salmonellosis intoxication are discussed.
研究了沙门氏菌病内毒素（SE）对大鼠空肠黏膜和肝脏胞质溶胶中谷胱甘肽转移酶（GT）、谷胱甘肽过氧化物酶（GP-GTB和GP-H2O2）、谷胱甘肽还原酶（GR）和超氧化物歧化酶（SOD）活性的影响。在SE作用的早期阶段，小肠和肝脏中所有测试酶的活性都发生了显著变化。因此，内毒素作用30分钟或1小时后，肝脏中SOD和GP-H2O2的活性分别下降。在空肠黏膜中，SE作用4小时后，GP-H2O2和SOD的活性下降。空肠中的GT保持不变，而肝脏中的GT被激活。肝脏和空肠中GR和GP-GTB的活性不同。讨论了抗氧化酶系统异常的原因和后果以及它们在沙门氏菌病中毒发病机制中所起的作用。
