Vasilenko A M, Barashkov G N, Zakharova L A
Biull Eksp Biol Med. 1984 Dec;98(12):696-8.
Transmitter peptides having immunostimulant and endorphine-like properties were isolated from supernatant of medullary cell culture. Bioregulatory peptides were called myelopeptides. Myelopeptides provoked changes of the summation-threshold index in rats, which augmented in time. These changes pointed to the realization of the analgetic effect of myelopeptides via the spinal-stem structures of the central nervous system. Having a remarkable analgesic effect myelopeptides administered in the doses tested did not produce any action on the behavioral responses. The latter circumstance makes them differ from narcotic analgesics and known endorphines.
具有免疫刺激和内啡肽样特性的递质肽是从髓细胞培养上清液中分离出来的。生物调节肽被称为骨髓肽。骨髓肽引起大鼠总和阈值指数的变化，这种变化随时间增加。这些变化表明骨髓肽通过中枢神经系统的脊髓干结构实现了镇痛作用。在测试剂量下给予的骨髓肽具有显著的镇痛作用，但对行为反应没有任何影响。后一种情况使它们与麻醉性镇痛药和已知的内啡肽不同。
