Lisianyĭ N I, Radzhievskiĭ A A, Zakharova L A
Biull Eksp Biol Med. 1988 Mar;105(3):310-1.
An immunocorrective effect of myelopeptides (MP) isolated from pig bone marrow cell culture supernatant in the early posttraumatic period in rats with severe cranial injury has been assessed. MP administration prevented cellular devastation of thymus and bone marrow, as well as spleen hyperplasia. The most marked MP effect was observed within the first 24 h after its administration. MP affected the functional and migration properties of both the entire population of lymphoid cells and individual subpopulations. MP had a pronounced protective effect against Staph. aureus infection during cranial trauma. MP completely prevented the death of animals and reduced more than 3-fold Staph. aureus persistence in the organism of animals. Anti-stress and protective effects of MP open vast prospects for their therapeutic and preventive application in the clinical practice.
评估了从猪骨髓细胞培养上清液中分离出的骨髓肽（MP）在重度颅脑损伤大鼠创伤后早期的免疫纠正作用。给予MP可预防胸腺、骨髓的细胞破坏以及脾脏增生。在给予MP后的最初24小时内观察到最显著的效果。MP影响了整个淋巴细胞群体和各个亚群的功能及迁移特性。MP对颅脑创伤期间的金黄色葡萄球菌感染具有显著的保护作用。MP完全预防了动物死亡，并使动物体内金黄色葡萄球菌的存留量减少了3倍以上。MP的抗应激和保护作用为其在临床实践中的治疗和预防应用开辟了广阔前景。
