Stepanenko V A, Romanova Iu A
Biull Eksp Biol Med. 1984 Dec;98(12):715-8.
Experiments on white random-bred male mice were made to study the effect of L-thyroxine on cell proliferation of the hyperdiploid strain of Ehrlich's ascites carcinoma. It was shown that upon prolonged thyroxine administration (during 6 days of carcinoma growth) the action of the latter appeared dose-dependent. The doses used were 1, 10, 30, 60, 100 micrograms/100 g bw. Circadian rhythms were noted in the sensitivity of the dividing cells to the hormone applied in a dose of 10 micrograms/100 g bw as was a certain decrease in the total level of the mitotic activity. At the same time thyroxine did not exert any noticeable effect on the average daily magnitudes of the number of DNA-synthesizing cells and did not change the pattern of modulations in the radioactive index. The changes in the mitotic index and radioactive index were asynchronous in control and experimental animals.
以白色随机繁殖雄性小鼠进行实验，研究L-甲状腺素对艾氏腹水癌超二倍体株细胞增殖的影响。结果表明，在长时间给予甲状腺素（在癌生长的6天期间）时，其作用呈剂量依赖性。所用剂量为1、10、30、60、100微克/100克体重。观察到分裂细胞对以10微克/100克体重剂量施用的激素的敏感性存在昼夜节律，同时有丝分裂活性的总水平有一定降低。与此同时，甲状腺素对DNA合成细胞数量的平均每日幅度没有产生任何明显影响，也没有改变放射性指数的调节模式。对照动物和实验动物的有丝分裂指数和放射性指数变化不同步。
