Romanov Iu A, Stepanenko V A
Biull Eksp Biol Med. 1985 Aug;100(8):228-9.
Experiments were made on randombred male mice weighing 18-20 g maintained on the light regimen L:D-12:12. The animals were given a single injection i. p. of a hypotetraploid subline of Ehrlich's ascites tumor. Fluctuations in the number of mitotic cells and no changes in the number of DNA-synthesizing cells were established. This indicates that synchronization of tumor cells under these conditions occurs mainly in the G2 phase. The results of the present experiments confirm those obtained during previous investigations, showing the lack of the dependence of the cell proliferation pattern on the cell ploidy. The disturbance of the chronobiological organization of tumor cell proliferation that is manifested by upset synchronization of cell division and DNA synthesis is common to all Ehrlich's ascites tumor sublines under study.
对体重18 - 20克、处于光照周期L:D - 12:12的随机繁殖雄性小鼠进行实验。给动物腹腔内单次注射艾氏腹水瘤的低四倍体亚系。确定有丝分裂细胞数量有波动，而DNA合成细胞数量无变化。这表明在这些条件下肿瘤细胞的同步化主要发生在G2期。本实验结果证实了先前研究中获得的结果，表明细胞增殖模式与细胞倍性无关。肿瘤细胞增殖的生物钟组织紊乱表现为细胞分裂和DNA合成同步性的破坏，在所研究的所有艾氏腹水瘤亚系中都是常见的。
