Crawley J N, Kiss J Z, Mezey E
Brain Res. 1984 Nov 26;322(2):316-21. doi: 10.1016/0006-8993(84)90124-0.
The mechanism by which peripherally administered cholecystokinin (CCK) reduces feeding and exploration involves a sensory feedback pathway from the gastrointestinal regions, via the vagus nerve through the nucleus tractus solitarius (NTS). Bilateral dorsal midbrain transections rostral to the NTS abolish the ability of CCK to reduce food consumption, decrease exploratory approaches, and increase pauses of behavioral inactivity, as compared to these actions of CCK in normal and sham-lesioned control rats, suggesting that ascending NTS fibers are a necessary component in this feedback system.
外周给予胆囊收缩素（CCK）减少进食和探索行为的机制涉及一条从胃肠道区域经迷走神经通过孤束核（NTS）的感觉反馈通路。与正常和假损伤对照大鼠中CCK的这些作用相比，在NTS前方进行双侧背侧中脑横切会消除CCK减少食物消耗、减少探索行为并增加行为静止期的能力，这表明NTS的上行纤维是该反馈系统的必要组成部分。
