Richards C L, Bouchard J P, Dumas F, Tardif D
Can J Neurol Sci. 1984 Nov;11(4 Suppl):554-60. doi: 10.1017/s0317167100035034.
We evaluated the effects of acetazolamide in 4 young patients with Friedreich's ataxia by clinical and quantitative laboratory methods. Dynamic muscle function of the lower extremity was measured during isokinetic knee movements and gait. The acetazolamide trial was terminated at 7 to 11 weeks because of reported side effects or increased ataxia in 3 of the patients. The quantitative evaluations revealed lower dynamic strength values and alterations in the gait movement pattern in all patients. These changes, which were interpreted as deterioration, were partially reversible with cessation of acetazolamide. The advantages of such quantitative evaluations of dynamic muscle function in the evaluation of therapy in Friedreich's ataxia are discussed.
我们通过临床和定量实验室方法评估了乙酰唑胺对4例弗里德赖希共济失调年轻患者的疗效。在等速膝关节运动和步态过程中测量下肢的动态肌肉功能。由于3例患者出现报告的副作用或共济失调加重，乙酰唑胺试验在7至11周时终止。定量评估显示所有患者的动态力量值较低，且步态运动模式发生改变。这些被解释为恶化的变化在停用乙酰唑胺后部分可逆。本文讨论了这种动态肌肉功能定量评估在弗里德赖希共济失调治疗评估中的优势。
