Woo J H, Ryu J K
Clin Ther. 1984;6(6):839-43.
Cefoperazone was used in the treatment of 23 cases of serious bacterial infection in 20 patients. Ten postoperative scalp wound infections, five infections at the site of tracheostomy, four cases of extradural spinal cord abscess, three cases of sepsis, and one abscess of the cerebellopontine angle were treated with cefoperazone (1 to 2 gm BID, usually for seven to 27 days). There were excellent or good clinical responses in 87% (20/23) of the cases (14 of the 15 postsurgical wound infections, three of the four cases of spinal cord abscess, and all three cases of sepsis). Most of the organisms isolated from the patients' cultures were sensitive to cefoperazone. Excellent or good responses occurred in ten of the 12 infections due to Staphylococcus aureus, in all three infections due to Pseudomonas sp, all three due to Citrobacter freundii, the two due to Serratia marcescens, one of the two due to Klebsiella sp, and the one due to Escherichia coli. Two patients with ventriculitis were clinically improved by three 1-gm infusions, via a shunt, of cefoperazone. No adverse effects of the antibiotic therapy were reported.
头孢哌酮用于治疗20例患者的23例严重细菌感染。其中10例术后头皮伤口感染、5例气管切开部位感染、4例硬脊膜外脊髓脓肿、3例败血症和1例桥小脑角脓肿接受了头孢哌酮治疗（每日2次，每次1至2克，通常用药7至27天）。87%（20/23）的病例临床反应良好或极佳（15例术后伤口感染中的14例、4例脊髓脓肿中的3例以及所有3例败血症）。从患者培养物中分离出的大多数微生物对头孢哌酮敏感。在12例由金黄色葡萄球菌引起的感染中，10例反应良好或极佳；在所有3例由假单胞菌属引起的感染、所有3例由弗氏柠檬酸杆菌引起的感染、2例由粘质沙雷氏菌引起的感染、2例由克雷伯菌属引起的感染中的1例以及1例由大肠杆菌引起的感染中，反应均良好或极佳。2例脑室炎患者通过经分流管输注3次1克头孢哌酮后临床症状改善。未报告抗生素治疗的不良反应。
