Mashimo K, Kunii O
Clin Ther. 1980;3(Spec Issue):159-72.
A total of 466 patients were treated with cefoperazone. The drug was usually administered by drip infusion of 2 to 4 gm/day. Therapy was described as markedly effective and moderately effective in 64 of 77 patients (83.1%) treated for urinary tract infections; 253 of 316 patients (80.1%) treated for respiratory infections; 37 of 48 patients (77.1%) treated for liver biliary duct infections; ten of 16 patients (62.5%) treated for septicemia; and seven of nine patients (77.8%) being treated for other infections. Overall, cefoperazone was effective 79.6% of all patients treated. With respect to bacteriological activity, the overall eradication rate for gram-negative organisms (including Pseudomonas aeruginosa, Klebsiella sp, Escherichia coli, Haemophilus influenzae, Enterobacter sp, and Proteus sp) was 81% (182/225) and for gram-positive (Staphyloccocus aureus, Streptococcus pneumoniae and Streptococcus faecalis) 90% (36/40). Of 205 patients who failed to respond to previous antibiotic therapy, 67.8% were treated effectively with cefoperazone. Side effects, such as skin eruption, pyrexia and diarrhea, occurred in only 4.8% of patients treated, while laboratory abnormalities, such as elevated glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, alkaline phosphatase, and eosinophil values, occurred in only 6.4% of the treated patients. None of these abnormal values were of clinical significance.
共有466例患者接受了头孢哌酮治疗。该药通常通过静脉滴注给药，剂量为每日2至4克。在77例接受尿路感染治疗的患者中，64例（83.1%）的治疗效果被描述为显著有效和中度有效；在316例接受呼吸道感染治疗的患者中，253例（80.1%）；在48例接受肝胆管感染治疗的患者中，37例（77.1%）；在16例接受败血症治疗的患者中，10例（62.5%）；在9例接受其他感染治疗的患者中，7例（77.8%）。总体而言，头孢哌酮对所有接受治疗的患者的有效率为79.6%。就细菌学活性而言，革兰氏阴性菌（包括铜绿假单胞菌、克雷伯菌属、大肠杆菌、流感嗜血杆菌、肠杆菌属和变形杆菌属）的总体根除率为81%（182/225），革兰氏阳性菌（金黄色葡萄球菌、肺炎链球菌和粪肠球菌）为90%（36/40）。在205例对先前抗生素治疗无反应的患者中，67.8%接受头孢哌酮治疗有效。副作用，如皮疹、发热和腹泻，仅发生在4.8%的接受治疗的患者中，而实验室异常，如谷草转氨酶、谷丙转氨酶、碱性磷酸酶和嗜酸性粒细胞值升高，仅发生在6.4%的接受治疗的患者中。这些异常值均无临床意义。
