大鼠肝脏中1-邻苯二甲酰基-5-氟尿嘧啶向5-氟尿嘧啶生物转化过程中的药物相互作用。
Drug interactions in biotransformation of 1-phthalidyl 5-fluorouracil to 5-fluorouracil in rat liver.
作者信息
Hirata M, Tonda K
出版信息
Chem Biol Interact. 1984 Dec;52(2):141-50. doi: 10.1016/0009-2797(84)90068-1.
PMID:6509684
Abstract
Two rat liver hydrolases were found to be involved in the metabolism of 1-phthalidyl 5-fluorouracil (PH-FU) to 5-fluorouracil (5-FU), one of which was induced by phenobarbital (PB) treatment of rats. Both inducible and constitutive enzyme were soluble and showed different characteristics in gel filtration and response to inhibitors. Further study showed that the blood level of PH-FU could be modulated by PB-pretreatment or coadministration of enzyme inhibitors to rats.
摘要
发现两种大鼠肝脏水解酶参与1-邻苯二甲酰基5-氟尿嘧啶（PH-FU）代谢生成5-氟尿嘧啶（5-FU）的过程，其中一种酶是通过用苯巴比妥（PB）处理大鼠诱导产生的。诱导型和组成型酶均为可溶性，在凝胶过滤和对抑制剂的反应方面表现出不同的特性。进一步研究表明，PB预处理或向大鼠共同给药酶抑制剂可调节PH-FU的血药浓度。
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