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Development of a low-dose monthly injectable contraceptive system: I. Choice of compounds, dose and administration route.

作者信息

Garza-Flores J, Diaz-Sanchez V, Jimenez-Thomas S, Rudel H W

出版信息

Contraception. 1984 Oct;30(4):371-9. doi: 10.1016/s0010-7824(84)80029-3.

DOI:10.1016/s0010-7824(84)80029-3
PMID:6509988
Abstract

A low-dose combined estrogen-progestogen sustained release system has been developed. The control of crystal size of the steroids produced sustained dissolution in vitro and in vivo. A dose-response experiment carried out in healthy women indicated that 10 mg of norethisterone (NET) with 1 mg of ethinylestradiol (EE2) when given by intramuscular injection maintained NET serum levels above 1 ng/ml for at least 25 days. The system is considered suitable for one month contraceptive protection.

摘要

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