Brenner P F, Goebelsmann U, Stanczyk F Z, Mishell D R
Contraception. 1980 Jul;22(1):85-95. doi: 10.1016/0010-7824(80)90120-1.
The pharmacodynamics of ethinylestradiol (EE2) were studied utilizing a specific radioimmunoassay to measure serum levels in subjects ingesting EE2 alone or in combination with various gestagens. Following the administration of a single oral dose of 20 micrograms of EE2 to three postmenopausal women, peak serum levels ranging from 29 to 58 pg/ml were reached within one hour. Levels fell below the sensitivity of the assay (20 pg/ml) 2, 5 and 8 hours after ingestion. In normal menstruating women, peak serum EE2 concentrations averaged 84 +/- 27 pg/ml after the ingestion of 35 micrograms EE2 and 0.5 mg norethindrone, 152 +/- 57 pg/ml after the ingestion of 50 micrograms mestranol and 1.0 norethindrone and 201 +/- 11 pg/ml after the ingestion of 50 micrograms EE2 and 0.5 mg norgestrel. After the ingestion of mestranol, peak serum levels of EE2 were less than and occurred later than peak levels obtained after the ingestion of the same dose of EE2.
利用一种特异性放射免疫分析法，对单独摄入乙炔雌二醇（EE2）或与各种孕激素联合摄入的受试者的血清水平进行测量，以研究EE2的药效学。给三名绝经后妇女单次口服20微克EE2后，一小时内血清峰值水平达到29至58皮克/毫升。摄入后2、5和8小时，水平降至该分析方法的灵敏度（20皮克/毫升）以下。在正常月经周期的妇女中，摄入35微克EE2和0.5毫克炔诺酮后，血清EE2峰值浓度平均为84±27皮克/毫升；摄入50微克炔雌醇甲醚和1.0毫克炔诺酮后，为152±57皮克/毫升；摄入50微克EE2和0.5毫克炔诺孕酮后，为201±11皮克/毫升。摄入炔雌醇甲醚后，EE2的血清峰值水平低于摄入相同剂量EE2后获得的峰值水平，且出现时间也更晚。
