Zuleta A, Basauri L
Childs Brain. 1984;11(6):418-27. doi: 10.1159/000120205.
4 cases of cloverleaf skull syndrome are reported and analyzed after a brief review of the literature is presented. It is noted that reported cases of surgical management of this entity are extraordinarily rare. The rather characteristic displacement of intracranial contents suggests early onset of craniosynostosis (in intrauterine life) and that hydrocephalus is not an invariable complication present at the time of birth. Rather, it appears that the hydrocephalus is secondary to obliteration of the cortical subarachnoid spaces and the presence of a cranial ring. Total craniectomy proved to be a satisfactory treatment, one which was responsible for the reversal of hydrocephalus. Early detection and treatment of this rather rare malformation results in acceptable cosmetic and neurologic improvement.
在简要回顾文献后，报告并分析了4例三叶草颅骨综合征病例。值得注意的是，关于该病症手术治疗的报道极为罕见。颅内内容物相当典型的移位提示颅缝早闭（在子宫内生活时）发病较早，且脑积水并非出生时必然存在的并发症。相反，脑积水似乎继发于皮质蛛网膜下腔闭塞和颅骨环的存在。全颅骨切除术被证明是一种令人满意的治疗方法，它使脑积水得到了逆转。早期发现并治疗这种相当罕见的畸形可带来可接受的外观和神经功能改善。
