乙醛对大鼠骨骼生成的影响。

Effect of acetaldehyde on skeletogenesis in rats.

作者信息

Sreenathan R N, Singh S, Padmanabhan R

出版信息

Drug Alcohol Depend. 1984 Oct;14(2):165-74. doi: 10.1016/0376-8716(84)90041-3.

Abstract

Acetaldehyde (ACH), the metabolite of ethanol was administered to pregnant CF rats intraperitoneally (50 mg/kg) from day 8 through 15 of gestation and fetuses from different mothers were collected from day 16 through 21 of gestation. Fetuses were processed for alizarin skeletal staining. There was significant delay in ossification besides certain skeletal malformations such as wavy ribs. The delay in ossification may be one of the reasons for reduced birth weight and increased postnatal mortality and growth.

摘要

乙醛（ACH）是乙醇的代谢产物，在妊娠第8天至15天对怀孕的囊性纤维化（CF）大鼠进行腹腔注射（50毫克/千克），并在妊娠第16天至21天收集来自不同母亲的胎儿。对胎儿进行茜素骨骼染色处理。除了某些骨骼畸形，如肋骨波浪状外，骨化出现了明显延迟。骨化延迟可能是出生体重降低、出生后死亡率增加和生长缓慢的原因之一。