Ternovoĭ K S, Derzhavin A E
Eksp Onkol. 1984;6(5):66-9.
The dynamics of distribution and removal of different types of magnetic microcarriers have been examined in 450 rats by the method of nuclear absorption spectrophotometry. The concentration of magnetic microcarriers was studied in the brain, heart, lungs, liver, spleen and kidneys in different periods (1 min to 30 days) after single intravenous injection of different types of magnetic fluids. The latter were prepared from the ultrafine powders of magnetite and metallic iron. The magnetic particles had a spherical form and varied from 10 to 70 nm in size. The results of studies have shown that microcarriers made of high-disperse metal iron are most preferable as drug carriers.
通过核吸收分光光度法，在450只大鼠身上研究了不同类型磁性微载体的分布和清除动态。在单次静脉注射不同类型磁性流体后的不同时间段（1分钟至30天），对脑、心脏、肺、肝脏、脾脏和肾脏中的磁性微载体浓度进行了研究。这些磁性流体由磁铁矿和金属铁的超细粉末制备而成。磁性颗粒呈球形，尺寸在10至70纳米之间。研究结果表明，由高分散金属铁制成的微载体作为药物载体最为理想。
