Sandyk R, Gillman M A
Eur Neurol. 1984;23(6):479-81. doi: 10.1159/000115732.
We report the occurrence of a partially reversible Parkinson-like extrapyramidal syndrome in a woman chronically exposed to vapours from an industrial solvent mixture based on trichlorotrifluoroethane and nitromethane. The fluoroalkane group of compounds has not been previously reported to produce such effects in man, but mixtures containing nitromethane may not be innocent. Under certain industrial conditions the conversion of nitromethane to methylisocyanide may result in toxicity particularly in the basal ganglia and cerebellum following chronic low level exposure.
我们报告了一名长期暴露于基于三氯三氟乙烷和硝基甲烷的工业溶剂混合物蒸汽中的女性出现了部分可逆的帕金森样锥体外系综合征。此前尚未有含氟烷类化合物对人体产生此类影响的报道，但含有硝基甲烷的混合物可能并非无害。在某些工业条件下，硝基甲烷转化为甲基异氰化物可能导致毒性，尤其是在长期低水平暴露后对基底神经节和小脑产生毒性。
