自发性高血压大鼠肾脏中的15-羟基前列腺素脱氢酶和己糖激酶
15-Hydroxyprostaglandin dehydrogenase and hexokinase in spontaneously hypertensive rat kidney.
作者信息
Corder C N, Bixenstine K J, Shapiro A P, Riehl W
出版信息
Experientia. 1984 Dec 15;40(12):1368-9. doi: 10.1007/BF01951893.
PMID:6510488
Abstract
15-Hydroxyprostaglandin dehydrogenase (PGDH) surged in hypertensive (SHR) and normotensive (WKY) rat kidney at 8 days of age, is greatest in SHR. Hexokinase fell in SHR at 17 days of age, but thereafter was similar to WKY. This suggests multisystem enzymatic abnormalities in SHR kidney during development of hypertension.
摘要
15-羟基前列腺素脱氢酶（PGDH）在8日龄的高血压大鼠（SHR）和正常血压大鼠（WKY）肾脏中激增，在SHR中最高。己糖激酶在17日龄的SHR中下降，但此后与WKY相似。这表明在高血压发展过程中，SHR肾脏存在多系统酶异常。
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