双去水半乳糖醇治疗晚期非鳞状宫颈癌的II期评估。一项妇科肿瘤学组研究。
Phase II evaluation of dianhydrogalactitol in the treatment of advanced non-squamous cervical carcinoma. A Gynecologic Oncology Group study.
作者信息
Stehman F B, Blessing J A, Homesley H D, Currie J L, Yordan E L
出版信息
Invest New Drugs. 1984;2(3):331-3. doi: 10.1007/BF00175387.
PMID:6511240
Abstract
In an on-going Phase II evaluation, dianhydrogalactitol (NSC 132313) was administered intravenously to 28 patients with advanced or recurrent non-squamous cell carcinoma of the cervix. The initial dosage was 60 mg/m2/wk with escalation to 75 mg/m2/wk if there were no adverse effects. Twenty-seven patients were evaluable for toxicity and response. There was one complete response and one partial response. Adverse effects were not infrequent but tolerable.
摘要
在一项正在进行的II期评估中，对28例晚期或复发性宫颈非鳞状细胞癌患者静脉注射了双去水半乳糖醇（NSC 132313）。初始剂量为60mg/m²/周，如果没有不良反应则增至75mg/m²/周。27例患者可评估毒性和反应。有1例完全缓解和1例部分缓解。不良反应并不罕见，但可以耐受。
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