Vogl S E, Seltzer V, Camacho F, Calanog A
Cancer Treat Rep. 1982 Oct;66(10):1809-12.
Eighteen evaluable patients with squamous cancer of the uterine cervix recurrent after radiation therapy or with distant metastases were treated with dianhydrogalactitol (150 mg/m2) and cisplatin (DDP) (50 mg/m2), both given iv every 3 weeks. Only 39% of the patients responded, a result no better than that previously reported for DDP alone and only one-half as good as that previously reported by our group for a combination of this drug with mitomycin, vincristine, and bleomycin. Responses lasted a median of only 5 months. Hematologic toxicity was life-threatening in 22% of the patients and was severe in all but 11% of the remaining patients. We conclude that the addition of substantial and toxic doses of dianhydrogalactitol to DDP failed to substantially enhance the rate, quality, or duration of response compared to DDP alone.
18例子宫颈鳞状癌患者在放疗后复发或有远处转移，接受了二去水半乳糖醇（150mg/m²）和顺铂（DDP）（50mg/m²）治疗，均每3周静脉给药一次。仅39%的患者有反应，这一结果并不比之前单独使用顺铂的报道更好，仅为我们小组之前报道的该药与丝裂霉素、长春新碱和博来霉素联合使用时效果的一半。反应持续时间的中位数仅为5个月。22%的患者出现危及生命的血液学毒性，其余患者中除11%外均为严重毒性。我们得出结论，与单独使用顺铂相比，在顺铂基础上加用大剂量且有毒性的二去水半乳糖醇并不能显著提高反应率、反应质量或反应持续时间。
