Utley J F, von Essen C F, Horn R A, Moeller J H
Int J Radiat Oncol Biol Phys. 1984 Dec;10(12):2259-63. doi: 10.1016/0360-3016(84)90231-1.
The Brachytron has been used in the University of California at San Diego Medical Center since 1970 as one method of treating gynecological malignancies. This machine contains a high intensity cobalt 60 remote afterloading cycling source used for intracavitary brachytherapy. One hundred twenty-seven patients with epithelial carcinoma of the cervix are available for analysis of 5-year survival, and 176 are analyzed for treatment complications two years following therapy. Five year survival figures for FIGO-staged patients treated with external beam pelvic irradiation and intracavitary Brachytron treatments are as follows: Stage I, 89%; Stage II, 58%; Stage III, 33%, and two of five patients Stage IVa. Rectal complications graded moderate or severe (M, S) were dose-related and gradually decreased over the years as techniques improved. Complications from early results in 1970-1972 (24% M, 10% S) were reduced to lower levels in 1976-1979 (14% M, 4% S). The Brachytron offers the advantage of rapid dose delivery. Thus, patients can be treated in an outpatient setting, avoiding the cost of hospitalization and the risks of anesthesia. The Brachytron also offers virtually complete radiation safety to all attending medical personnel. With survival and complication figures similar to those reported for patients treated with conventional low-dose-rate brachytherapy, the Brachytron represents an effective alternate mode of therapy for uterine carcinoma.
自1970年以来，短距离治疗机（Brachytron）一直在加利福尼亚大学圣地亚哥分校医学中心用于治疗妇科恶性肿瘤。这台机器包含一个高强度钴60远程后装循环源，用于腔内近距离放射治疗。127例子宫颈上皮癌患者可用于5年生存率分析，176例患者在治疗两年后接受治疗并发症分析。采用盆腔外照射和腔内短距离治疗机治疗的国际妇产科联盟（FIGO）分期患者的5年生存率如下：I期，89%；II期，58%；III期，33%，IVa期5例中有2例。中度或重度（M，S）直肠并发症与剂量相关，随着技术的改进，这些并发症多年来逐渐减少。1970 - 1972年早期结果中的并发症（24%为中度，10%为重度）在1976 - 1979年降至较低水平（14%为中度，4%为重度）。短距离治疗机具有快速给药的优势。因此，患者可以在门诊环境中接受治疗，避免了住院费用和麻醉风险。短距离治疗机还为所有参与治疗的医务人员提供了几乎完全的辐射安全保障。由于其生存率和并发症数据与传统低剂量率近距离放射治疗患者报告的数据相似，短距离治疗机是子宫癌一种有效的替代治疗方式。
