Waldrop T G, Millhorn D E, Eldridge F L, Klingler L E
J Appl Physiol Respir Environ Exerc Physiol. 1984 Dec;57(6):1738-41. doi: 10.1152/jappl.1984.57.6.1738.
Respiratory responses to increased skin temperatures were recorded in anesthetized cerebrate and in unanesthetized decerebrate cats. All were vagotomized, glomectomized, and paralyzed. Core body temperature and end-tidal Pco2 were kept constant with servoncontrollers. Stimulation of cutaneous nociceptors by heating the skin to 46 degrees C caused respiration to increase in both cerebrate and decerebrate cats. An even larger facilitation of respiration occurred when the skin temperature was elevated to 51 degrees C. However, respiration did not increase in either group of cats when the skin was heated to 41 degrees C to activate cutaneous warm receptors. The phenomenon of sensitization of nociceptors was observed. Spinal transection prevented all the respiratory responses to cutaneous heating. We conclude that noxious, but not nonnoxious, increases in skin temperature cause increases in respiratory output.
在麻醉的大脑完整猫和未麻醉的去大脑猫身上记录了对皮肤温度升高的呼吸反应。所有动物均进行了迷走神经切断术、球切除术并使其麻痹。通过伺服控制器使核心体温和呼气末二氧化碳分压保持恒定。将皮肤加热至46摄氏度刺激皮肤伤害感受器会导致大脑完整猫和去大脑猫的呼吸均增加。当皮肤温度升高至51摄氏度时，呼吸促进作用甚至更大。然而，当皮肤加热至41摄氏度以激活皮肤温觉感受器时，两组猫的呼吸均未增加。观察到了伤害感受器的敏化现象。脊髓横断可阻止对皮肤加热的所有呼吸反应。我们得出结论，皮肤温度的有害但非无害升高会导致呼吸输出增加。
