Waldrop T G, Eldridge F L, Millhorn D E
Respir Physiol. 1982 Nov;50(2):239-54. doi: 10.1016/0034-5687(82)90021-4.
Respiratory responses, measured from phrenic nerve activity, to stimulation of limb muscles or their afferent nerves were studied in anesthetized cats with intact brains, after cerebellectomy or decortication, and in unanesthetized decerebrate animals. All were vagotomized, glomectomized and paralyzed. Body temperature and end-tidal PCO2 were kept constant with servocontrollers. Nerve or muscle stimulation in animals with intact brains caused an increase in respiration which was followed by a respiratory afterdischarge, both of which have been described previously. In addition, stimulation of either muscle or nerve in animals with intact brains caused a post-stimulation depression of respiration that persisted for up to an hour. Decerebrated animals or those with spinal cord transection at cervical, thoracic or lumbar levels did not develop the response. In decorticated or decerebellated animals, the magnitude of the prolonged inhibition was markedly decreased. We conclude that: (1) stimulation of limb muscles or their afferent nerves activates a central neural mechanism which causes a prolonged depression of respiration; (2) the afferent input involved in this response is transmitted to the brain via spinal cord pathways; and (3) the cerebellum and suprapontine brain are required for full development of the post-stimulation inhibition.
在完整大脑的麻醉猫、小脑切除或去皮质后的麻醉猫以及未麻醉的去大脑动物中，研究了通过膈神经活动测量的对肢体肌肉或其传入神经刺激的呼吸反应。所有动物均进行了迷走神经切断、球囊切除并使其麻痹。体温和呼气末二氧化碳分压通过伺服控制器保持恒定。完整大脑动物的神经或肌肉刺激会导致呼吸增加，随后出现呼吸后放电，这两者此前均有描述。此外，完整大脑动物的肌肉或神经刺激会导致刺激后呼吸抑制，持续长达一小时。去大脑动物或在颈、胸或腰段进行脊髓横断的动物未出现这种反应。在去皮质或去小脑的动物中，延长抑制的程度明显降低。我们得出以下结论：(1) 刺激肢体肌肉或其传入神经会激活一种中枢神经机制，导致呼吸长期抑制；(2) 参与该反应的传入输入通过脊髓通路传输至大脑；(3) 小脑和脑桥以上的脑对于刺激后抑制的充分发展是必需的。
