Murphy J C, Fox J G, Niemi S M
J Am Vet Med Assoc. 1984 Dec 1;185(11):1359-62.
A 6% incidence of nephrotic syndrome was noted in a colony of 400 Syrian hamsters (Mesocricetus auratus) over a period of 2 years. Clinical findings consisted of severe ascites and anasarca, anorexia, cachexia, and papular dermatitis. Serum and urine chemical analysis revealed proteinuria and hypoalbuminemia in all animals tested; hypoproteinemia and high concentrations of serum cholesterol, triglycerides, and creatinine were detected in some of the affected hamsters. Demodex aurati was detected in skin scrapings from 4 of 8 hamsters. Necropsy findings included subcutaneous edema, ascites, and hydrothorax, as well as atrophic kidneys and testes. Extensive deposits of type AA amyloid were detected histologically in kidney, liver, spleen, and adrenal gland; smaller deposits were found in thyroid gland and intestine. Other histologic findings included periodontitis and hyalinization of the small arteries of the testes.
在一个由400只叙利亚仓鼠（金仓鼠）组成的群体中，经过2年的观察发现肾病综合征的发病率为6%。临床症状包括严重腹水、全身水肿、厌食、恶病质和丘疹性皮炎。血清和尿液化学分析显示，所有受试动物均有蛋白尿和低白蛋白血症；部分患病仓鼠检测出低蛋白血症以及血清胆固醇、甘油三酯和肌酐浓度升高。在8只仓鼠中的4只皮肤刮片中检测到耳螨。尸检结果包括皮下水肿、腹水、胸腔积液，以及肾脏和睾丸萎缩。组织学检查发现，肾脏、肝脏、脾脏和肾上腺中有大量AA型淀粉样蛋白沉积；甲状腺和肠道中也发现了较小的沉积物。其他组织学发现包括牙周炎和睾丸小动脉玻璃样变。
