Mezza L E, Quimby F W, Durham S K, Lewis R M
Lab Anim Sci. 1984 Aug;34(4):376-80.
Amyloid from 16 Syrian hamsters with spontaneous age-related systemic amyloidosis retained affinity for Congo red dye after treatment with potassium permanganate. Serum electrophoresis showed a slight rise in gamma globulins without a monoclonal spike. Bence-Jones proteins were not present in the urine. There was no histological evidence of plasmacytosis. Amyloidosis could not be associated with chronic inflammation. The lack of apparent etiology of this amyloid and its resistance to potassium permanganate treatment suggests that it is a primary non-AA amyloid. This finding varies with a report suggesting that the spontaneous amyloidosis of aged Syrian hamsters is associated with the AA fibril.
16只患有自发性年龄相关性系统性淀粉样变性的叙利亚仓鼠的淀粉样蛋白在用高锰酸钾处理后仍保留对刚果红染料的亲和力。血清电泳显示γ球蛋白略有升高，无单克隆峰。尿中未检测到本斯·琼斯蛋白。没有浆细胞增多的组织学证据。淀粉样变性与慢性炎症无关。这种淀粉样蛋白缺乏明显病因且对高锰酸钾治疗有抗性，提示它是原发性非AA型淀粉样蛋白。这一发现与一份报告不同，该报告表明老年叙利亚仓鼠的自发性淀粉样变性与AA原纤维有关。
