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克林霉素与头孢咪唑（U63196E）在体外对需氧革兰氏阴性杆菌和需氧革兰氏阳性球菌的相互作用。

Interaction of clindamycin and cefpimizole (U63196E) in vitro against aerobic gram-negative rods and aerobic gram-positive cocci.

作者信息

Welch W D, Bawdon R E, Luttrell B, Goodson S

出版信息

J Antimicrob Chemother. 1984 Nov;14(5):553-6. doi: 10.1093/jac/14.5.553.

DOI:10.1093/jac/14.5.553
PMID:6511709
Abstract

The combination of clindamycin plus a new semisynthetic cephalosporin, U63196E for which the United States approved name is cefpimizole, was tested against 47 aerobic Gram-negative rods and 30 aerobic Gram-positive cocci. Synergy was seen with Klebsiella pneumoniae (3 of 19 isolates) and Escherichia coli (2 of 21 isolates). All isolates of Pseudomonas aeruginosa, Staphylococcus aureus, methicillin-resistant Staph. aureus, and enterococci demonstrated either indifference or antagonistic reactions to the drug combination.

摘要

对克林霉素与一种新型半合成头孢菌素（美国批准名称为头孢咪唑，即U63196E）的联合用药进行了针对47株需氧革兰氏阴性杆菌和30株需氧革兰氏阳性球菌的测试。在肺炎克雷伯菌（19株分离株中的3株）和大肠杆菌（21株分离株中的2株）中观察到协同作用。所有铜绿假单胞菌、金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和肠球菌的分离株对该药物组合均表现出无反应或拮抗反应。

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