Johnson D E, Riley M G, Cornish H H
J Appl Toxicol. 1984 Oct;4(5):253-7. doi: 10.1002/jat.2550040508.
1-Nitronaphthalene (1-NN) produced respiratory distress and centrilobular liver necrosis in male Sprague-Dawley rats after a single intraperitoneal injection (100 mg kg-1). Microscopic examination of the lungs of rats killed 24 h after the injection revealed a highly selective non-ciliated bronchiolar (Clara) cell necrosis as the only remarkable lesion. Pretreatment of animals with phenobarbital offered complete protection from the respiratory distress induced by 1-NN, but increased the severity of the hepatotoxicity. Pretreatment with SKF-525A protected against 1-NN-induced liver necrosis, but did not alter the incidence or severity of the respiratory distress. Under similar conditions, this pattern of toxicity was not seen with the structural analogue 2-nitronaphthalene.
单次腹腔注射（100毫克/千克）1-硝基萘（1-NN）后，雄性斯普拉格-道利大鼠出现呼吸窘迫和小叶中心性肝坏死。对注射后24小时处死的大鼠肺部进行显微镜检查发现，唯一显著的病变是高度选择性的无纤毛细支气管（克拉拉）细胞坏死。用苯巴比妥预处理动物可完全保护其免受1-NN诱导的呼吸窘迫，但会增加肝毒性的严重程度。用SKF-525A预处理可防止1-NN诱导的肝坏死，但不会改变呼吸窘迫的发生率或严重程度。在类似条件下，结构类似物2-硝基萘未出现这种毒性模式。
