Yoshida A, Fujita M, Owada E, Ito K
J Pharmacobiodyn. 1984 Aug;7(8):511-6. doi: 10.1248/bpb1978.7.511.
Effects of diltiazem hydrochloride (DTZ) on digoxin (DX) concentrations in plasma and tissues (brain, heart, liver, and kidney) were studied in mice, and the effects were compared with those of quinidine sulfate (QD). When DX (0.2 mg/kg) was coadministered with DTZ (60 mg/kg) orally for 5 d to mice, plasma DX concentrations were increased significantly as with QD (100 mg/kg). Tissue DX concentrations were also increased in brain, heart, and liver. However, the DX tissue/plasma concentration (T/P) ratios for brain, heart, and kidney were rather decreased with DTZ or QD. The increased plasma and tissue DX concentrations and the decreased T/P ratios with DTZ might be responsible for both the displacement of tissue DX binding and reduced DX elimination as with QD.
在小鼠中研究了盐酸地尔硫䓬（DTZ）对血浆及组织（脑、心脏、肝脏和肾脏）中地高辛（DX）浓度的影响，并将这些影响与硫酸奎尼丁（QD）的影响进行了比较。当将DX（0.2mg/kg）与DTZ（60mg/kg）口服共同给予小鼠5天时，血浆DX浓度与QD（100mg/kg）一样显著升高。脑、心脏和肝脏中的组织DX浓度也升高。然而，DTZ或QD使脑、心脏和肾脏的DX组织/血浆浓度（T/P）比值有所降低。DTZ使血浆和组织DX浓度升高以及T/P比值降低，这可能与QD一样是由于组织DX结合的置换和DX消除减少所致。
