Katoh R, Nishio Y, Itoh T, Kimura R, Fukuta Y, Tomichi N, Yagawa K, Ono T, Bessho K
Gan No Rinsho. 1984 Oct;30(13):1700-6.
A case of undifferentiated carcinoma of the thyroid gland with osteoclast-like giant cells resembling those of a giant cell tumor of the bone is presented. A 79-year-old female had noticed swelling on the left frontal neck. Histological examination of frontal-neck tumor revealed undifferentiated carcinoma of the thyroid gland. The patient was treated with a Cobalt 60 unit and received a total tumor dose of 2800 rad. However, because of a rapid increase in size of the tumor and its metastasis, the patient died about 2 months after admission. An autopsy was performed. Histologically, the tumor differed from the usual undifferentiated carcinoma of the giant cell type in having osteoclast-like giant cells with many small, uniform, benign appearing nuclei. It is proposed that the osteoclast-like giant cell is reactive rather than neoplastic in nature because of the benign appearance, phagocytotic activity and some ultrastructural features.
本文报告一例甲状腺未分化癌，其破骨细胞样巨细胞类似于骨巨细胞瘤。一名79岁女性发现左颈前部肿胀。对颈前部肿瘤进行组织学检查，结果显示为甲状腺未分化癌。该患者接受了钴60治疗，肿瘤总剂量为2800拉德。然而，由于肿瘤迅速增大并发生转移，患者在入院后约2个月死亡。进行了尸检。组织学上，该肿瘤与通常的巨细胞型未分化癌不同，其破骨细胞样巨细胞具有许多小的、均匀的、看似良性的细胞核。鉴于其良性外观、吞噬活性和一些超微结构特征，推测破骨细胞样巨细胞本质上是反应性的而非肿瘤性的。
