青年和老年鸡血清胆固醇水平、淋巴细胞质膜流动性与丝裂原反应性之间缺乏相关性。

Lack of correlation between serum cholesterol levels, lymphocyte plasma membrane fluidity and mitogen responsiveness in young and aged chickens.

作者信息

Traill K N, Ratheiser K, Dietrich H, Sailer S, Zevenbergen J L, Wick G

出版信息

Mech Ageing Dev. 1984 Nov;28(1):123-38. doi: 10.1016/0047-6374(84)90158-1.

Abstract

Chickens were studied in an attempt to demonstrate correlations between serum lipid levels and peripheral blood lymphocyte (PBL) plasma membrane fluidity and mitogen responsiveness: (a) in the laying hen; (b) during aging; and (c) following dietary manipulation of serum cholesterol of young and aged chickens. The membrane fluidity of PBL from laying hens was significantly greater than that of immature birds. However, no direct correlation was found between serum lipid levels, nor the serum free cholesterol/phospholipid (FC/Pl) mole composition and PBL membrane fluidity in any of the age-groups tested. Likewise, no correlation was found either between serum FC/Pl mole ratio or membrane fluidity and mitogen responsiveness of PBL from birds up to 5 years of age nor was there any evidence for a decline in mitogen responsiveness up to this age. Supplementation of diets with 1% cholesterol induced hypercholesterolemia, mainly in the very low density lipoprotein (VLDL) fraction, but membrane fluidity and mitogen responsiveness remained unaffected.

摘要

对鸡进行了研究，旨在证明血清脂质水平与外周血淋巴细胞（PBL）质膜流动性及丝裂原反应性之间的相关性：（a）产蛋母鸡；（b）衰老过程中；（c）对年轻和老龄鸡进行饮食调控血清胆固醇之后。产蛋母鸡PBL的膜流动性显著高于未成熟鸡。然而，在所测试的任何年龄组中，血清脂质水平、血清游离胆固醇/磷脂（FC/Pl）摩尔组成与PBL膜流动性之间均未发现直接相关性。同样，在5岁以下鸡中，血清FC/Pl摩尔比或膜流动性与PBL的丝裂原反应性之间也未发现相关性，且在此年龄之前也没有丝裂原反应性下降的证据。在日粮中添加1%胆固醇会诱发高胆固醇血症，主要存在于极低密度脂蛋白（VLDL）部分，但膜流动性和丝裂原反应性仍未受影响。