Tucker R M, Strong C G, Brennan L A, Sheps S G, Brown R D, Weinshilboum R M
Mayo Clin Proc. 1978 Jun;53(6):373-7.
Fifteen patients whose renovascular hypertension was cured or improved by renal artery reconstructive surgery or nephrectomy (or both) underwent studies of their renin-angiotensin systems preoperatively. These studies included measurements of peripheral venous renin activity in the erect position without diuretic preparation, blood pressure response to blockade of endogenous angiotensin II with a saralasin infusion in the acutely sodium-depleted state, and levels of renal venous renin activity, also after sodium depletion. In 13 of these 15 patients who had benefitted from surgical intervention for relief of renovascular hypertension, at least one index of renin dependency was positive. Two patients had negative results in all of the tests. On the basis of these findings, we concluded that cure or improvement of renovascular hypertension is possible even though these three parameters of renin-angiotensin overactivity are negative.
15例因肾动脉重建手术或肾切除术（或两者皆有）而使肾血管性高血压得到治愈或改善的患者，在术前接受了肾素-血管紧张素系统的研究。这些研究包括在未使用利尿剂准备的直立位测量外周静脉肾素活性、在急性缺钠状态下用沙拉新输注阻断内源性血管紧张素II时的血压反应，以及缺钠后肾静脉肾素活性水平。在这15例因手术干预缓解肾血管性高血压而受益的患者中，有13例至少一项肾素依赖性指标呈阳性。2例患者所有检查结果均为阴性。基于这些发现，我们得出结论，即使肾素-血管紧张素过度活跃的这三个参数为阴性，肾血管性高血压仍有可能治愈或改善。
