血小板衍生生长因子诱导c-fos基因和蛋白的快速但短暂的表达。
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein.
作者信息
Kruijer W, Cooper J A, Hunter T, Verma I M
出版信息
Nature. 1984;312(5996):711-6. doi: 10.1038/312711a0.
DOI:10.1038/312711a0
PMID:6514007
Abstract
Exposure of quiescent mouse fibroblasts to platelet-derived growth factor induces mRNA from the c-fos proto-oncogene within 10 min followed by synthesis of nuclear c-fos proteins. These are amongst the earliest described nuclear events that follow a mitogenic stimulus.
摘要
将静止的小鼠成纤维细胞暴露于血小板衍生生长因子下，10分钟内即可诱导原癌基因c-fos的mRNA产生，随后合成核c-fos蛋白。这些是有丝分裂刺激后最早被描述的核事件。
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