Mügge A, Reupcke C, Schmitz W, Scholz H
Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):90-3. doi: 10.1007/BF00496113.
The positive inotropic effect of (-)-phenylephrine, in the presence of propranolol, was studied after inhibition of neuronal and extraneuronal uptake in isolated papillary muscles from reserpine-pretreated cats. An inhibition of extraneuronal uptake with hydrocortisone influenced the effect of (-)-phenylephrine neither when present alone nor in the presence of cocaine (additional inhibition of neuronal uptake). An inhibition of neuronal uptake with cocaine caused a small but significant increase in the potency of (-)-phenylephrine. We conclude that in cat ventricular cardiac muscle the extraneuronal compartment is apparently neither a "site of loss" nor a "site of gain" for (-)-phenylephrine with respect to force of contraction.
在利血平预处理的猫的离体乳头肌中，抑制神经元和非神经元摄取后，研究了普萘洛尔存在下（-）-去氧肾上腺素的正性肌力作用。单独使用氢化可的松抑制非神经元摄取，或在存在可卡因（额外抑制神经元摄取）时，均不影响（-）-去氧肾上腺素的作用。用可卡因抑制神经元摄取导致（-）-去氧肾上腺素的效力有小幅但显著的增加。我们得出结论，在猫心室心肌中，就收缩力而言，非神经元区室显然既不是（-）-去氧肾上腺素的“失活部位”也不是“增效部位”。
