Abbott E M, Parkins J J, Holmes P H
Parasitology. 1984 Dec;89 ( Pt 3):585-96. doi: 10.1017/s003118200005678x.
An experiment was conducted to examine, under laboratory conditions, the pathophysiology of chronic ovine haemonchosis. In the present study, groups of Merino and Scottish Blackface lambs were maintained on a low plane of nutrition and infected with 50 Haemonchus contortus larvae/kg live weight. The parasitized lambs along with respective breed controls were examined over a 27-week period. In addition to the body weight, haematological and parasitological parameters, erythrokinetic, metabolic, digestibility and nitrogen balance studies were conducted in the early stages of the infection. The results demonstrated that a low level of infection with H. contortus in lambs on a poor plane of nutrition caused the development of a normochromic normocytic anaemia which was associated with a modest but significant increase in abomasal blood loss and slightly elevated erythropoiesis in both breeds relative to the controls. The level of anaemia, hypoproteinaemia and pathophysiological changes were more marked in the Merino lambs and they also had higher faecal egg counts than the Blackface lambs.
进行了一项实验，在实验室条件下研究慢性绵羊捻转血矛线虫病的病理生理学。在本研究中，将美利奴羊和苏格兰黑脸羊羔羊分组，维持低营养水平，并按每千克活重感染50条捻转血矛线虫幼虫。在27周的时间里对受寄生虫感染的羔羊及其各自品种的对照羊进行检查。除了体重、血液学和寄生虫学参数外，还在感染早期进行了红细胞动力学、代谢、消化率和氮平衡研究。结果表明，营养水平差的羔羊感染低水平的捻转血矛线虫会导致正色素正细胞性贫血的发生，这与两个品种相对于对照羊皱胃失血量适度但显著增加以及红细胞生成略有升高有关。美利奴羊羔羊的贫血、低蛋白血症水平和病理生理变化更为明显，并且它们的粪虫卵计数也高于黑脸羊羔羊。
