Abbott E M, Parkins J J, Holmes P H
University of Glasgow Veterinary School.
Res Vet Sci. 1988 Jul;45(1):41-9.
Mixed-sex groups of three-month-old Finn Dorset and Dorset Horn lambs were given complete diets containing either high or low protein. A trickle infection with Haemonchus contortus of 200 larvae, given three times a week, began one month later for a 17 week period. Erythrokinetic, metabolic, digestibility and balance studies were conducted with the male lambs during weeks 12 to 14 of the infection. Clinical signs of haemonchosis became evident only in the low protein diet group. The infection was characterised by severe macrocytic anaemia, hypoproteinaemia, hypoalbuminaemia, reduced survival, high egg counts and a significantly greater worm burden. In the high protein diet group many lambs developed resistance to further infection in contrast to the low protein group in which no resistance developed. Live-weight gain was not affected by infection in the high protein diet group but decreased in the lambs given the low protein diet compared with uninfected controls. However, infection did not appear adversely to affect the digestive efficiency, nitrogen retention or iron absorption in either dietary group although loss of appetite occurred in the low protein group. Examination of a sample joint from the carcases showed infection was associated with a marked reduction in muscle mass in lambs given the low protein diet relative to the control animals.
将三个月大的芬兰多塞特和多塞特角杂交羔羊按性别混合分组，分别给予高蛋白或低蛋白的全价日粮。一个月后，开始为期17周的捻转血矛线虫感染实验，每周三次，每次感染200条幼虫。在感染的第12至14周期间，对雄性羔羊进行了红细胞动力学、代谢、消化率和平衡研究。捻转血矛线虫病的临床症状仅在低蛋白日粮组中明显。感染的特征为严重的大细胞性贫血、低蛋白血症、低白蛋白血症、存活率降低、高虫卵计数以及明显更高的虫负荷。与未产生抗性的低蛋白组相比，高蛋白日粮组中的许多羔羊对进一步感染产生了抗性。高蛋白日粮组的感染未影响体重增加，但与未感染的对照组相比，低蛋白日粮组羔羊的体重增加减少。然而，尽管低蛋白组出现食欲减退，但感染似乎未对任何一个日粮组的消化效率、氮保留或铁吸收产生不利影响。对 carcasses 的一个样本关节进行检查发现，与对照动物相比，低蛋白日粮组羔羊的感染与肌肉量的显著减少有关。
