Klinefelter B B, Youtz S L, Wideman R F
Poult Sci. 1984 Nov;63(11):2285-91. doi: 10.3382/ps.0632285.
Previous work has shown that parathyroid hormone causes the kidneys of domestic fowl to secrete inorganic phosphate (Pi) into the urine. Secreted Pi is not derived directly from plasma Pi. The objective of the present study was to determine if direct or indirect correlations exist between the urinary Pi excretion rate and the concentration of phosphate in plasma or whole blood. Parathyroid hormone dissolved in gelatin carrier vehicle was injected into immature domestic fowl to cause net renal Pi secretion. Control birds were injected with carrier vehicle alone, resulting in net Pi reabsorption. Urine, plasma, and whole blood samples obtained during net Pi secretion were compared with samples obtained during net Pi reabsorption. Each sample was assayed for total and inorganic phosphate. Neither time course nor point by point comparisons of individual samples provided any evidence that secreted Pi is derived from organic phosphate in plasma or whole blood. These experiments suggest that phosphate pools within the kidneys may serve as a source for the Pi that is secreted in response to parathyroid hormone.
先前的研究表明，甲状旁腺激素会促使家禽的肾脏将无机磷酸盐（Pi）分泌到尿液中。分泌出的Pi并非直接来源于血浆中的Pi。本研究的目的是确定尿Pi排泄率与血浆或全血中磷酸盐浓度之间是否存在直接或间接的相关性。将溶解在明胶载体中的甲状旁腺激素注射到未成熟的家禽体内，以引起肾脏净Pi分泌。对照家禽仅注射载体，导致Pi净重吸收。将净Pi分泌期间获得的尿液、血浆和全血样本与净Pi重吸收期间获得的样本进行比较。对每个样本进行总磷酸盐和无机磷酸盐分析。无论是时间进程还是单个样本的逐点比较，都没有提供任何证据表明分泌出的Pi来源于血浆或全血中的有机磷酸盐。这些实验表明，肾脏内的磷酸盐池可能是响应甲状旁腺激素而分泌的Pi的来源。
