Thompson T, Honor J, Verchota S, Cleary J
Pharmacol Biochem Behav. 1984 Nov;21(5):743-7. doi: 10.1016/s0091-3057(84)80013-1.
The effects of methadone hydrochloride on lever pressing rats maintained under multiple fixed-interval and fixed-ratio, or multiple variable-interval and variable-ratio reinforcement schedules equated for reinforcement density were examined. Under a multiple fixed-interval, fixed-ratio schedule overall response rate was decreased during both components but was most affected under the ratio schedule. Response rate decreases were due primarily to changes in running rate rather than pause time. Under a multiple variable-interval, variable-ratio schedule, overall response rate was also decreased by methadone, with the greatest decrease again occurring during the ratio schedule. These schedule-specific methadone effects are not due to differences in reinforcement frequency. Evidence for rate-dependency with methadone is not consistent across subjects.
研究了盐酸美沙酮对在多重固定间隔和固定比率、或多重可变间隔和可变比率强化程序下维持的杠杆按压大鼠的影响，这些强化程序的强化密度相等。在多重固定间隔、固定比率程序下，两个成分的总体反应率均降低，但在比率程序下受影响最大。反应率降低主要是由于奔跑速度的变化而非停顿时间的变化。在多重可变间隔、可变比率程序下，美沙酮也降低了总体反应率，比率程序期间再次出现最大降幅。这些特定程序的美沙酮效应并非由于强化频率的差异。美沙酮的速率依赖性证据在不同个体间并不一致。
