Hamilton J M, Heller H W, Wade G N
Physiol Behav. 1984 Sep;33(3):373-8. doi: 10.1016/0031-9384(84)90156-2.
Male rats fed a cellulose-diluted diet maintained a reduced body weight. Adipose tissue lipoprotein lipase (LPL) activity decreased after two days of cellulose feeding, but was not different from chow-fed control levels with weight stabilized at 90% or 70% of the control group. Plasma triglyceride concentration decreased with weight loss and remained depressed with stabilized reduced weight. Regaining lost weight had no effect on LPL activity when compared with chow-fed controls or with levels obtained for the weight-reduced group. However, plasma triglyceride concentration returned to chow-fed control levels with weight gain. The disparity between these results and those obtained in obese human beings lends support to the hypothesis that the increase in adipose tissue LPL activity in weight-reduced obese human beings is indicative of a defect in regulation of adipose tissue metabolism.
喂食纤维素稀释饮食的雄性大鼠体重持续减轻。喂食纤维素两天后，脂肪组织脂蛋白脂肪酶（LPL）活性降低，但当体重稳定在对照组的90%或70%时，该活性与喂食普通饲料的对照组水平并无差异。血浆甘油三酯浓度随体重减轻而降低，且在体重稳定减轻时仍保持较低水平。与喂食普通饲料的对照组或体重减轻组的水平相比，体重恢复对LPL活性没有影响。然而，随着体重增加，血浆甘油三酯浓度恢复到喂食普通饲料的对照组水平。这些结果与在肥胖人群中获得的结果之间的差异支持了这样一种假设，即体重减轻的肥胖人群脂肪组织LPL活性的增加表明脂肪组织代谢调节存在缺陷。
