Morphological markers with predictive-evolutive value in liver diseases.

A morphological, endoscopic and bioptic (histologic and electron microscopic) study carried out in 86 patients with acute persisting hepatitis (APH) and 240 patients with noncirrhogenous alcoholic hepatitis (AH) allowed the observation of some aspects with predictive-evolutive value in liver diseases. In APH the endoscopic observation of a change of colour from bright red to variegated and the appearance on histologic examination of portal infiltrate with invasive tendency as well as of collagen spurs penetrating in the portal spaces, suggest the onset of the chronicity. In AH the changes with predictive value present in both AH and hepatic steatosis are, the alterations of the liver surface, and especially perivenular and perisynusoidal fibrosis.