Trasler D G, Trasler T A
Teratology. 1984 Dec;30(3):423-7. doi: 10.1002/tera.1420300315.
Newborn litters of the L line and CL/Fr and A/JFr strains were examined, and sex, frequency and type of cleft lip (left, right or bilateral) were recorded. Embryos and fetuses from crosses between these strains and line were collected on days 13 to 16 of gestation, and frequency and type of cleft lip recorded. Overall cleft frequencies in L X CL/Fr, CL/Fr X L, and CL/Fr X A/JFr crosses (female stated first) were similar, while in A/JFr X L (10.3%) they were significantly lower than in L X A/JFr (23.3%). The data suggested that the same maternal effect genes were present in CL/Fr and the related L line and absent from A/JFr. In the L, CL/Fr, and A/JFr newborns, there was a tendency for males to have higher frequencies of cleft lip and bilateral cleft lip and the latter was significant for L. Left cleft lip frequency was significantly higher than right for L and CL/Fr newborns and in embryos of the CL/Fr X L and L X CL/Fr cross. No significant differences in laterality were found in the A/JFr strain, A/JFr X L, L X A/JFr, and CL/Fr X A/JFr crosses. It was concluded that (1) the embryonic and maternal effect genes for cleft lip are similar or identical in CL/Fr and L; and (2) using data from the literature, there are additional genetic factor(s) increasing left cleft lip occurrence acting in the embryo, which are present in CL/Fr, L, A/HeJ, A/He, and A/St and absent from A/JKt, A/J, A/JFr, and A/WySn.
对L系以及CL/Fr和A/JFr品系的新生仔鼠进行了检查，并记录了唇裂的性别、频率和类型（左侧、右侧或双侧）。在妊娠第13至16天收集这些品系和品系间杂交产生的胚胎和胎儿，并记录唇裂的频率和类型。L×CL/Fr、CL/Fr×L以及CL/Fr×A/JFr杂交组合（雌性在前）的总体唇裂频率相似，而在A/JFr×L杂交组合中（10.3%），其唇裂频率显著低于L×A/JFr杂交组合（23.3%）。数据表明，CL/Fr和相关的L系存在相同的母体效应基因，而A/JFr中不存在。在L、CL/Fr和A/JFr新生仔鼠中，雄性唇裂和双侧唇裂的频率有升高趋势，对于L系而言，后者差异显著。L和CL/Fr新生仔鼠以及CL/Fr×L和L×CL/Fr杂交组合胚胎的左侧唇裂频率显著高于右侧。在A/JFr品系、A/JFr×L、L×A/JFr以及CL/Fr×A/JFr杂交组合中，未发现左右侧有显著差异。得出的结论是：（1）CL/Fr和L中唇裂的胚胎和母体效应基因相似或相同；（2）根据文献数据，胚胎中存在其他增加左侧唇裂发生率的遗传因素，这些因素存在于CL/Fr、L、A/HeJ、A/He和A/St中，而不存在于A/JKt、A/J、A/JFr和A/WySn中。
