Juriloff D M
Teratology. 1982 Jun;25(3):361-8. doi: 10.1002/tera.1420250313.
The frequency of spontaneous cleft lip on Day 14 of gestation was examined in the A/J, A/HeJ, A/WySn, A.BY/Sn, A.SW/Sn, B10.A/SgSn, and B10.A(2R)/SgSn inbred strains of mice. A/WySn was found to have a higher frequency of cleft lip (20-30%) than A/J or A/HeJ (10%). Differences among strains in laterality of clefting and in rates of differential mortality of affected embryos were also found. Results of crosses between A/WySn and A/HeJ suggested that the difference in rate of clefting may be due to a genetic maternal effect. The results for A.BY/Sn, A.SW/Sn, B10.A/SgSn and B10.A(2R)/SgSn indicated that no association of cleft lip liability and the H-2 complex was detectable.
在A/J、A/HeJ、A/WySn、A.BY/Sn、A.SW/Sn、B10.A/SgSn和B10.A(2R)/SgSn等近交系小鼠中，研究了妊娠第14天唇裂的自发频率。发现A/WySn的唇裂频率（20%-30%）高于A/J或A/HeJ（10%）。还发现各品系在唇裂的侧向性以及受影响胚胎的差异死亡率方面存在差异。A/WySn和A/HeJ之间的杂交结果表明，唇裂发生率的差异可能是由于遗传母体效应。A.BY/Sn、A.SW/Sn、B10.A/SgSn和B10.A(2R)/SgSn的结果表明，未检测到唇裂易感性与H-2复合体之间的关联。
