Sabnis S G, Gunson D E, Antonovych T T
Vet Pathol. 1984 Nov;21(6):574-81. doi: 10.1177/030098588402100605.
Seven horses ranging from three to 15 years of age had nephrotic syndrome; at necropsy, renal tissue of all seven horses had the morphologic lesions of mesangioproliferative glomerulonephritis (membranoproliferative glomerulonephritis). Homogeneous eosinophilic material which filled the glomerular capillary lumina was found in five horses. Ultrastructurally, this material primarily consisted of electron-dense deposits with a fibrillar pattern in five horses and in one horse, rhomboid crystalline deposits which resembled deposits seen in human cryoglobulinemia. The association of mesangioproliferative glomerulonephritis with cryoglobulinemia is well documented in man. The presence of intracapillary deposits, with the histologic and ultrastructural lesion of mesangioproliferative glomerulonephritis, suggests a similar association in these horses.
7匹年龄在3至15岁之间的马患有肾病综合征；尸检时，所有7匹马的肾组织都有系膜增生性肾小球肾炎（膜增生性肾小球肾炎）的形态学病变。在5匹马中发现了填充肾小球毛细血管腔的均质嗜酸性物质。超微结构上，这种物质在5匹马中主要由具有纤维状模式的电子致密沉积物组成，在1匹马中为菱形晶体沉积物，类似于人类冷球蛋白血症中所见的沉积物。系膜增生性肾小球肾炎与冷球蛋白血症的关联在人类中有充分记录。毛细血管内沉积物的存在，以及系膜增生性肾小球肾炎的组织学和超微结构病变，提示这些马中存在类似的关联。
