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冷球蛋白血症相关性肾小球肾炎的超微结构。6例报告及文献复习。

Ultrastructure in glomerulonephritis associated with cryoglobulinemia. A report of six cases and review of the literature.

作者信息

Feiner H, Gallo G

出版信息

Am J Pathol. 1977 Jul;88(1):145-62.

PMID:879268
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2032161/
Abstract

Renal tissue from 6 patients with glomerulonephritis associated with cryoglobulinemia was studied by light microscopy, immunofluorescence microscopy, and electron microscopy. Fibrillar deposits in glomerular capillaries were observed in electron micrographs in 4 of 6 patients. The ultrastructure of these deposits is compared with those in 6 previously reported cases, with the ultrastructure of the serum cryoprecipitates, and with fibrillar glomerular deposits in other glomerulonephritides. It is concluded that serum cryoprecipitates are structurally similar to glomerular deposits and that these fibrillar deposits are a frequent and possibly distinguishing morphologic feature of glomerulonephritis associated with cryoglobulinemia.

摘要

对6例伴有冷球蛋白血症的肾小球肾炎患者的肾组织进行了光镜、免疫荧光显微镜和电子显微镜检查。在6例患者中的4例电子显微镜照片中观察到肾小球毛细血管中有纤维状沉积物。将这些沉积物的超微结构与6例先前报道病例中的沉积物、血清冷沉淀物的超微结构以及其他肾小球肾炎中的纤维状肾小球沉积物进行了比较。得出的结论是，血清冷沉淀物在结构上与肾小球沉积物相似，并且这些纤维状沉积物是伴有冷球蛋白血症的肾小球肾炎常见且可能具有鉴别意义的形态学特征。

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本文引用的文献

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Systemic lupus erythematosus. Cryoprecipitation of sera.系统性红斑狼疮。血清冷沉淀反应
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Ultrastructural immunohistochemical localization of polyclonal IgG, C3, and amyloid P component on the congo red-negative amyloid-like fibrils of fibrillary glomerulopathy.多克隆IgG、C3和淀粉样蛋白P成分在纤维性肾小球病刚果红阴性淀粉样纤维上的超微结构免疫组化定位
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Paraproteinemia and cryoglobulinemia associated with atypical glomerulonephritis and the nephrotic syndrome.副蛋白血症和冷球蛋白血症与非典型肾小球肾炎及肾病综合征相关。
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Unusual findings in the human renal glomerulus in multiple myeloma. A light- and electron-microscopic study.多发性骨髓瘤患者肾小球的异常发现。光镜和电镜研究。
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