Karimov M A, Artamonova L A, Ermolenko A S
Vopr Onkol. 1984;30(12):40-5.
The carcinogenic effect of treatment with heavy catalytic gasoil on the skin of 120 albino noninbred mice was studied. Skin tumors arose in 97 of 115 animals (84.3%) which survived until the appearance of the first papillomas. In 21 mice, tumors were benign while cancer developed in 76 animals. 116 visceral neoplasms were detected in 99 animals (93.4%). They were found in the upper part of digestive tract of 57, the hematopoietic and lymphatic tissues of 57 and in the lungs of two animals. The study established a high carcinogenicity of heavy catalytic gasoil matched by early appearance and multicentric growth of tumors as well as rapid generalization of the process.
研究了重催化瓦斯油处理对120只非近亲白化小鼠皮肤的致癌作用。在115只存活至出现首个乳头状瘤的动物中，有97只（84.3%）出现了皮肤肿瘤。21只小鼠的肿瘤为良性，76只动物发生了癌症。在99只动物（93.4%）中检测到116个内脏肿瘤。它们出现在57只动物的消化道上部、57只动物的造血和淋巴组织以及2只动物的肺部。该研究证实了重催化瓦斯油具有高度致癌性，其特点是肿瘤出现早、多中心生长以及病程迅速扩散。
