Cattaino G, Querin F, Pomes A, Piazza P
Acta Neurol Scand. 1984 Dec;70(6):385-90. doi: 10.1111/j.1600-0404.1984.tb00842.x.
30 patients aged between 45 and 78 years and who had suffered from transient global amnesia (TGA), were seen at the Department of Neurology, Pordenone Public Hospital, in the period 1978 to 1982. 25 patients had one or more risk factors for cerebrovascular disease, such as hypertension, cardiac abnormalities, diabetes and hyperlipidemia. EEG examination revealed abnormal activity only in 7 patients. Brain Computed Tomography showed cerebral atrophy in 10 and hypodense lesions in 3 patients. 16 patients had been followed up for a mean interval of 20 months. During the follow-up period, 4 patients had recurrent TGA and one had a transient ischemic attack in the vertebrobasilar arterial system. In the follow-up group, 15 patients showed permanent memory impairment. The high incidence of risk factors for cerebrovascular disease seems to confirm that TGA is probably due to transient cerebral ischemia. The high rate of permanent memory impairment, almost always connected with the coexistence of cerebrovascular risk factors, is not in agreement with the postulated good prognosis of TGA.
1978年至1982年期间，在波代诺内公立医院神经内科诊治了30例年龄在45至78岁之间、患有短暂性全面性遗忘症（TGA）的患者。25例患者有一个或多个脑血管疾病危险因素，如高血压、心脏异常、糖尿病和高脂血症。脑电图检查仅在7例患者中发现异常活动。脑部计算机断层扫描显示10例有脑萎缩，3例有低密度病变。16例患者接受了平均20个月的随访。随访期间，4例患者复发TGA，1例在椎基底动脉系统发生短暂性脑缺血发作。在随访组中，15例患者出现永久性记忆障碍。脑血管疾病危险因素的高发生率似乎证实TGA可能是由短暂性脑缺血引起的。永久性记忆障碍的高发生率几乎总是与脑血管危险因素并存有关，这与TGA假定的良好预后不一致。
